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D-panthenol, or pro-vitamin B5, is an active ingredient with exceptional moisturizing properties that help to repair and protect the skin's barrier. Its anti-inflammatory effects also make it an effective ingredient for soothing and calming irritated skin.


D-Panthenol, also known as pro-Vitamin B5 or dexpanthenol, is a versatile ingredient that has numerous benefits for the skin. Since its first use in an ointment, various product types have been developed which are widely used in the field of dermatology and skin care, and are associated with high consumer satisfaction It is widely used in skincare products to moisturize, soothe, and protect dry, dehydrated, and irritated skins.


Typically, D-Panthenol is used at concentrations ranging from 1 to 10% in skincare products The concentration used may vary based on the specific formulation and intended use.

Who Should Use It

D-Panthenol is suitable for all skin types and is especially beneficial for those with dry or sensitive skin. It can help to restore the skin’s natural moisture balance, lock in hydration, and protect it from environmental pollutants. It is also an effective skin-soothing ingredient for those with atopic-prone skin, and irritated and sun-burned skin.

Can Be Used In Combination With

D-Panthenol is known to have a synergistic effect when used in combination with other ingredients like Madecassoside, Niacinamide, Superoxide Dismutase, Ascorbic Acid, Retinol, and Isoflavones.

How Often Can You Use It

D-Panthenol can be used daily, in the morning and/or in the evening, depending on the specific formulation and individual skin needs.

Don't Use It If

D-panthenol is suitable for all skin types. If you have very sensitive skin or allergies, it is always recommended to test products on a small skin area before using them on the face.

Origins of the Ingredient

D-Panthenol is derived from pantothenic acid, which is a naturally occurring B-complex vitamin. It is commonly found in a variety of food sources like eggs, whole grains, and dairy products. In 1944,  the first topical d-panthenol-containing formulation was commercialized as an ointment. The D-Panthenol used by Universkin is a high-purity grade, produced synthetically.

Chemical Composition

D-Panthenol is a provitamin of pantothenic acid.It is composed of two main components: alcohol and acid. The alcohol component helps to attract and retain moisture, while the acid component helps to strengthen the skin barrier. Dexpanthenol is a stable alcoholic analog of pantothenic acid. Contrary to pantothenic acid, it is well absorbed through the skin. It comes in a white crystalline powder.

Mechanism of Action

Although discovered decades ago, the exact mechanisms of action of d-panthenol have not been fully elucidated yet. However, it is clearly demonstrated that D-Panthenol is converted into pantothenic acid once it is absorbed into the skin. It is thought to act in three main ways: first, by increasing skin renewal, which helps to keep the skin healthy and well-maintained. Secondly, by protecting the skin from damage caused by free radicals, which are molecules that can cause damage to the skin’s cells. Finally, by improving the skin’s protective barrier, which can help keep the skin hydrated and well-nourished. In addition, d-panthenol is known to help reduce inflammation signs. It then functions as a moisturizing and repairing agent, helping to improve the overall health and appearance of the skin.


One of the major benefits of using products with D-panthenol is that it has a moisturizing effect. It helps to draw moisture into the skin, leaving it looking and feeling softer and smoother. Additionally, it helps to create a barrier on the skin that prevents environmental damage and protects against environmental irritants.  D-panthenol is also known to help reduce inflammation signs. This makes it especially helpful for those with sensitive, reactive, and dry skin like atopic prone skin. The anti-inflammatory action helps to reduce redness and irritation, as well as to promote skin repair.


D-Panthenol is a relatively stable ingredient.

In conclusion, D-Panthenol is a versatile ingredient that can be used to help moisturize and repair the skin. Its properties make it suitable for all skin types, including sensitive and reactive skin, and it has been shown to effectively reduce dryness and dehydration, making the skin more flexible and resilient. D-Panthenol is a valuable addition to any skincare routine.